TRNA pseudouridine38/39 synthase explained

tRNA pseudouridine^38/39 synthase
Ec Number:	5.4.99.45

tRNA pseudouridine^38/39 synthase (Deg1, Pus3p, pseudouridine synthase 3) is an enzyme with systematic name tRNA-uridine^38/39 uracil mutase.^{[1] [2]} This enzyme catalyses the following chemical reaction

tRNA uridine^38/39

\rightleftharpoons tRNA pseudouridine^38/39

The enzyme from Saccharomyces cerevisiae is active only towards uridine³⁸ and uridine³⁹.

See also

• PUS1
• Mitochondrial tRNA pseudouridine27/28 synthase

Notes and References

1. Lecointe F, Simos G, Sauer A, Hurt EC, Motorin Y, Grosjean H . Characterization of yeast protein Deg1 as pseudouridine synthase (Pus3) catalyzing the formation of psi 38 and psi 39 in tRNA anticodon loop . The Journal of Biological Chemistry . 273 . 3 . 1316–23 . January 1998 . 9430663 . 10.1074/jbc.273.3.1316 . free .
2. Chen J, Patton JR . Pseudouridine synthase 3 from mouse modifies the anticodon loop of tRNA . Biochemistry . 39 . 41 . 12723–30 . October 2000 . 11027153 . 10.1021/bi001109m .