Decylhomocitrate synthase explained

decylhomocitrate synthase
Ec Number:	2.3.3.4
Cas Number:	51845-40-0
Go Code:	0050458

In enzymology, a decylhomocitrate synthase is an enzyme that catalyzes the chemical reaction

dodecanoyl-CoA + H₂O + 2-oxoglutarate

\rightleftharpoons (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA

The 3 substrates of this enzyme are dodecanoyl-CoA, H₂O, and 2-oxoglutarate, whereas its two products are (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate and CoA.

This enzyme belongs to the family of transferases, specifically those acyltransferases that convert acyl groups into alkyl groups on transfer. The systematic name of this enzyme class is dodecanoyl-CoA:2-oxoglutarate C-dodecanoyltransferase (thioester-hydrolysing, 1-carboxyundecyl-forming). Other names in common use include 2-decylhomocitrate synthase, 3-hydroxytetradecane-1,3,4-tricarboxylate 2-oxoglutarate-lyase, and (CoA-acylating).

References

• Mahlen A . 1973 . Purification and some properties of 2-decylhomocitrate synthase from Penicillium spiculisporum . Eur. J. Biochem. . 38 . 32 - 9 . 4774124 . 10.1111/j.1432-1033.1973.tb03029.x . 1 . free .
• L, Narendra AM, Mehra NK, Saxena R, Choudhry VP . 2006 . Fludarabine, cyclophosphamide and horse antithymocyte globulin conditioning regimen for allogeneic peripheral blood stem cell transplantation performed in non-HEPA filter rooms for multiply transfused patients with severe aplastic anemia . Bone Marrow Transplant. . 37 . 745 - 9 . 16518427 . 10.1038/sj.bmt.1705321 . 8 .