Decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase explained

Decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase
Ec Number:1.1.1.333

Decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase (decaprenylphospho-beta-D-ribofuranose 2'-epimerase, Rv3791, DprE2) is an enzyme with systematic name trans,octacis-decaprenylphospho-beta-D-arabinofuranose:NAD+ 2-oxidoreductase.[1] This enzyme catalyses the following chemical reaction

trans,octacis-decaprenylphospho-beta-D-arabinofuranose + NAD+

\rightleftharpoons

trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose + NADH + H+

The reaction is catalysed in the reverse direction.

Notes and References

  1. Trefzer C, Škovierová H, Buroni S, Bobovská A, Nenci S, Molteni E, Pojer F, Pasca MR, Makarov V, Cole ST, Riccardi G, Mikušová K, Johnsson K . Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-β-D-ribofuranose 2'-oxidase DprE1 . Journal of the American Chemical Society . 134 . 2 . 912–5 . January 2012 . 22188377 . 10.1021/ja211042r .

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