Decaprenyl-phosphate phosphoribosyltransferase explained

Decaprenyl-phosphate phosphoribosyltransferase
Ec Number:2.4.2.45

Decaprenyl-phosphate phosphoribosyltransferase (5-phospho-alpha-D-ribose-1-diphosphate:decaprenyl-phosphate 5-phosphoribosyltransferase, 5-phospho-alpha-D-ribose 1-pyrophosphate:decaprenyl phosphate 5-phosphoribosyltransferase, DPPR synthase, Rv3806) is an enzyme with systematic name trans,octacis-decaprenylphospho-beta-D-ribofuranose 5-phosphate:diphosphate phospho-alpha-D-ribosyltransferase.[1] This enzyme catalyses the following chemical reaction

trans,octacis-decaprenyl phosphate + 5-phospho-alpha-D-ribose 1-diphosphate

\rightleftharpoons

trans,octacis-decaprenylphospho-beta-D-ribofuranose 5-phosphate + diphosphate

This enzyme requires Mg2+. It is isolated from Mycobacterium tuberculosis.

Notes and References

  1. Huang H, Scherman MS, D'Haeze W, Vereecke D, Holsters M, Crick DC, McNeil MR . Identification and active expression of the Mycobacterium tuberculosis gene encoding 5-phospho--d-ribose-1-diphosphate: decaprenyl-phosphate 5-phosphoribosyltransferase, the first enzyme committed to decaprenylphosphoryl-d-arabinose synthesis . The Journal of Biological Chemistry . 280 . 26 . 24539–43 . July 2005 . 15878857 . 10.1074/jbc.m504068200 . free .

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