Desacetoxyvindoline Explained

Desacetoxyvindoline is a terpene indole alkaloid produced by the plant Catharanthus roseus. Desacetoxyvindoline is a product formed by the methylation of the nitrogen on the indole ring by the enzyme 3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase (NMT).[1] The metabolite is a substrate for desacetoxyvindoline 4-hydroxylase (D4H) which catalyzes a hydroxylation to yield deacetylvindoline.[2]

Notes and References

  1. Liscombe . DK . Usera . AR . O'Connor . SE . Homolog of tocopherol C methyltransferases catalyzes N methylation in anticancer alkaloid biosynthesis. . Proceedings of the National Academy of Sciences of the United States of America . 2 November 2010 . 107 . 44 . 18793–8 . 10.1073/pnas.1009003107 . 20956330. 2973921 . 2010PNAS..10718793L . free .
  2. Vazquez-Flota . Felipe . De Carolis . Emidio . Alarco . Anne-Marie . De Luca . Vincenzo . Molecular cloning and characterization of desacetoxyvindoline-4-hydroxylase, a 2-oxoglutarate dependent-dioxygenase involved in the biosynthesis of vindoline in Catharanthus roseus (L.) G. Don . Plant Molecular Biology . 1997 . 34 . 6 . 935–948 . 10.1023/A:1005894001516. 9290645 . 33942703 .

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