Damnacanthal Explained

Damnacanthal is an anthraquinone isolated from the root of Morinda citrifolia, using water^[1] or organic solvents.^[2]

Pharmacology

In a 1995 in vitro study, damnacanthal was found to act as a potent and selective inhibitor of p56lck tyrosine kinase.^[3]

Notes and References

1. Anekpankul T, Goto M, Sasaki M . Extraction of anti-cancer damnacanthal from roots of Morinda citrifolia by subcritical water . Separation and Purification Technology. 55 . 3 . 343–349 . July 2007 . 10.1016/j.seppur.2007.01.004 . etal.
2. 21212526 . 10.1248/bpb.34.103 . 34 . 1 . The antinociceptive and anti-inflammatory action of the CHCl3-soluble phase and its main active component, damnacanthal, isolated from the root of Morinda citrifolia . 2011 . Biol Pharm Bull . 103–7 . Okusada K, Nakamoto K, Nishida M, Fujita-Hamabe W, Kamiya K, Mizushina Y, Satake T, Tokuyama S . free .
3. Faltynek CR, Schroeder J, Mauvais P . Damnacanthal is a highly potent, selective inhibitor of p56lck tyrosine kinase activity . Biochemistry . 34 . 38 . 12404–10 . September 1995 . 7547985 . 10.1021/bi00038a038. etal.