Dammarenediol II synthase explained

Dammarenediol II synthase
Ec Number:4.2.1.125
Cas Number:189354-84-5

Dammarenediol II synthase (dammarenediol synthase, 2,3-oxidosqualene (20S)-dammarenediol cyclase, DDS, (S)-squalene-2,3-epoxide hydro-lyase (dammarenediol-II forming)) is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene hydro-lyase (dammarenediol-II forming).[1] [2] This enzyme catalyses the following chemical reaction

dammarenediol II

\rightleftharpoons

(3S)-2,3-epoxy-2,3-dihydrosqualene + H2O

The reaction occurs in the reverse direction.

Notes and References

  1. Tansakul P, Shibuya M, Kushiro T, Ebizuka Y . Dammarenediol-II synthase, the first dedicated enzyme for ginsenoside biosynthesis, in Panax ginseng . FEBS Letters . 580 . 22 . 5143–9 . October 2006 . 16962103 . 10.1016/j.febslet.2006.08.044 .
  2. Han JY, Kwon YS, Yang DC, Jung YR, Choi YE . Expression and RNA interference-induced silencing of the dammarenediol synthase gene in Panax ginseng . Plant & Cell Physiology . 47 . 12 . 1653–62 . December 2006 . 17088293 . 10.1093/pcp/pcl032 . free .