| Dwarfin sma | |
| Organism: | Caenorhabditis elegans |
| Taxid: | 6239 |
| Symbol: | daf-8 |
| Entrezgene: | 187612 |
| Refseqmrna: | NM_059920.3 |
| Refseqprotein: | NP_492321.1 |
| Uniprot: | Q21733 |
| Chromosome: | I |
| Entrezchromosome: | NC_003279.8 |
| Genloc Start: | 8584081 |
| Genloc End: | 8587505 |
The DAF-8 nematode gene encoding a R-SMAD protein of TGF-beta signaling pathway, which was originally found in model organism Caenorhabditis elegans.[1] When the TGF-β ligand daf-7 binds to the TGF-β receptors daf-1/daf-4 on the surface of nematode cell, daf-8 will be phosphorylated and forms a heterodimer with daf-14, then enter to the nucleus to inhibit transcription regulated by daf-3/daf-5.[2]