Daf-7 Explained

abnormal dauer formation protein 7
Organism:	Caenorhabditis elegans
Taxid:	6239
Symbol:	daf-7
Entrezgene:	175237
Homologene:	21183
Refseqmrna:	NM_064864.5
Refseqprotein:	NP_497265.1
Uniprot:	P92172
Chromosome:	III
Entrezchromosome:	NC_003281.10
Genloc Start:	811828
Genloc End:	813773

The DAF-7 gene encodes for the ortholog of GDF11, a ligand of TGF-beta signaling pathway, in the worm Caenorhabditis elegans.^[1] When binds to the complex of type II receptor Daf-4 and type I receptor Daf-1, this receptor protein serine/threonine kinase will phosphorylation activate the Smad Protein Daf-8/14.^[2]

Notes and References

1. Morita K, Shimizu M, Shibuya H, Ueno N . A DAF-1-binding protein BRA-1 is a negative regulator of DAF-7 TGF-beta signaling . Proceedings of the National Academy of Sciences of the United States of America . 98 . 11 . 6284–8 . May 2001 . 11353865 . 10.1073/pnas.111409798 . 33460 . 2001PNAS...98.6284M . free .
2. Krishna S, Maduzia LL, Padgett RW . Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans . Development . 126 . 2 . 251–60 . January 1999 . 10.1242/dev.126.2.251 . 9847239 . 2460114 .