Daf-5 Explained

Dauer Formation abnormality gene 5
Organism:Caenorhabditis elegans
Taxid:6239
Symbol:Daf-5
Entrezgene:175054
Refseqmrna:NM_064540.5
Refseqprotein:NP_496941.1
Uniprot:G5EDM7
Chromosome:II
Entrezchromosome:NC_003280.10
Genloc Start:14033233
Genloc End:14037721

Daf-5 is an ortholog of the mammalian protein Sno/Ski,which present in the nematode worm Caenorhabditis elegans on the downstream of TGFβ signaling pathway.[1] Without daf-7 signal, daf-5 combined with daf-3, co-SMAD for C. elegans, to form a heterodimer and started dauer development.[2]

Notes and References

  1. da Graca LS, Zimmerman KK, Mitchell MC, Kozhan-Gorodetska M, Sekiewicz K, Morales Y, Patterson GI . 31708102 . DAF-5 is a Ski oncoprotein homolog that functions in a neuronal TGF beta pathway to regulate C. elegans dauer development . Development . 131 . 2 . 435–46 . January 2004 . 14681186 . 10.1242/dev.00922 . free .
  2. Gumienny TL, Savage-Dunn C . TGF-β signaling in C. elegans . WormBook . 1–34 . July 2013 . 23908056 . 5081272 . 10.1895/wormbook.1.22.2 .