Daf-4 Explained

abnormal dauer formation protein 4
Organism:	Caenorhabditis elegans
Taxid:	6239
Symbol:	daf-4
Entrezgene:	175781
Homologene:	124563
Uniprot:	P50488
Chromosome:	III
Genloc Start:	5625014
Genloc End:	5632322

The DAF-4 gene encodes for the only type II receptor of TGF-beta signaling pathway in the worm Caenorhabditis elegans,^[1] with the ligands Daf-7 or Dbl-1.^[2] When binds to the ligand Daf-7, Daf-4 complexed with the type I receptor Daf-1, and activated the Smad Protein Daf-8/14. By contrast, when binds to Dbl-1, Daf-4 complexed with the Sma-6 type I receptor, and activated the Sma-2/3/4.^[3]

Notes and References

1. Morita K, Shimizu M, Shibuya H, Ueno N . A DAF-1-binding protein BRA-1 is a negative regulator of DAF-7 TGF-beta signaling . Proceedings of the National Academy of Sciences of the United States of America . 98 . 11 . 6284–8 . May 2001 . 11353865 . 10.1073/pnas.111409798 . 33460 . 2001PNAS...98.6284M . free .
2. Savage C, Das P, Finelli AL, Townsend SR, Sun CY, Baird SE, Padgett RW . Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components . Proceedings of the National Academy of Sciences of the United States of America . 93 . 2 . 790–4 . January 1996 . 8570636 . 10.1073/pnas.93.2.790 . 40134. 1996PNAS...93..790S . free .
3. Krishna S, Maduzia LL, Padgett RW . Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans . Development . 126 . 2 . 251–60 . January 1999 . 10.1242/dev.126.2.251 . 9847239 . 2460114 .