| Dwarfin sma | |
| Organism: | Caenorhabditis elegans |
| Taxid: | 6239 |
| Symbol: | daf-3 |
| Entrezgene: | 180431 |
| Refseqmrna: | NM_075760.6 |
| Refseqprotein: | NP_508161.3 |
| Uniprot: | Q95QI7 |
| Chromosome: | X |
| Entrezchromosome: | NC_003284.9 |
| Genloc Start: | 817927 |
| Genloc End: | 825475 |
The DAF-3 or Dwarfin sma is a nematode Caenorhabditis elegans gene encoding a Co-SMAD protein of TGF-beta signaling pathway. Without daf-7 signal, DAF-3 combined with transcription factor daf-5 to form a heterodimer and started dauer development. When daf-7 binds to the receptors daf-1/daf-4, the phosphorylated daf-8/daf-14 heterodimer enter to the nucleus to inhibit this transcription.[1]