Daf-1 Explained

abnormal dauer formation protein 1
Organism:	Caenorhabditis elegans
Taxid:	6239
Symbol:	daf-1
Entrezgene:	176829
Homologene:	134382
Uniprot:	P20792
Chromosome:	IV
Genloc Start:	132416
Genloc End:	138076

The DAF-1 gene encodes for a cell surface Enzyme-linked receptor of TGF-beta signaling pathway in the worm Caenorhabditis elegans.^[1] DAF-1 is one of the type I receptor of TGF-beta pathway.^[2] DAF-1 acts as a receptor protein serine/threonine kinase, is activated by type II receptor Daf-4 phosphorylation after the ligand Daf-7 binds to the receptor heterotetramer, and then phosphorylates Daf-8 or Daf-14, the SMAD proteins in C. elegans.^[3]

Notes and References

1. Georgi LL, Albert PS, Riddle DL . daf-1, a C. elegans gene controlling dauer larva development, encodes a novel receptor protein kinase . Cell . 61 . 4 . 635–45 . May 1990 . 2160853 . 10.1016/0092-8674(90)90475-t . 205020137 .
2. Morita K, Shimizu M, Shibuya H, Ueno N . A DAF-1-binding protein BRA-1 is a negative regulator of DAF-7 TGF-beta signaling . Proceedings of the National Academy of Sciences of the United States of America . 98 . 11 . 6284–8 . May 2001 . 11353865 . 10.1073/pnas.111409798 . 33460 . 2001PNAS...98.6284M . free .
3. Krishna S, Maduzia LL, Padgett RW . Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans . Development . 126 . 2 . 251–60 . January 1999 . 10.1242/dev.126.2.251 . 9847239 . 2460114 .