DTDP-4-dehydro-6-deoxyglucose reductase explained

dTDP-4-dehydro-6-deoxyglucose reductase
Ec Number:	1.1.1.266
Go Code:	0050573

In enzymology, a dTDP-4-dehydro-6-deoxyglucose reductase is an enzyme that catalyzes the chemical reaction

dTDP-D-fucose + NADP⁺

\rightleftharpoons dTDP-4-dehydro-6-deoxy-D-glucose + NADPH + H⁺

Thus, the two substrates of this enzyme are dTDP-D-fucose and NADP⁺, whereas its 3 products are dTDP-4-dehydro-6-deoxy-D-glucose, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is dTDP-D-fucose:NADP⁺ oxidoreductase. This enzyme is also called dTDP-4-keto-6-deoxyglucose reductase. This enzyme participates in polyketide sugar unit biosynthesis.

References

• Yoshida Y, Nakano Y, Nezu T, Yamashita Y, Koga T . 1999 . A novel NDP-6-deoxyhexosyl-4-ulose reductase in the pathway for the synthesis of thymidine diphosphate-D-fucose . J. Biol. Chem. . 274 . 16933 - 9 . 10358040 . 10.1074/jbc.274.24.16933 . 24 . free .