DTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase explained

DTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase
Ec Number:	2.1.1.235

DTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase (TylM1) is an enzyme with systematic name S-adenosyl-L-methionine:dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose 3-N,N-dimethyltransferase.^{[1] [2]} This enzyme catalyses the following chemical reaction

2 S-adenosyl-L-methionine + dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose

\rightleftharpoons 2 S-adenosyl-L-homocysteine + dTDP-3-dimethylamino-3,6-dideoxy-alpha-D-glucopyranose

The enzyme is involved in the biosynthesis of mycaminose.

Notes and References

1. Chen H, Yamase H, Murakami K, Chang CW, Zhao L, Zhao Z, Liu HW . Expression, purification, and characterization of two N,N-dimethyltransferases, tylM1 and desVI, involved in the biosynthesis of mycaminose and desosamine . Biochemistry . 41 . 29 . 9165–83 . July 2002 . 12119032 . 10.1021/bi020245j .
2. Carney AE, Holden HM . Molecular architecture of TylM1 from Streptomyces fradiae: an N,N-dimethyltransferase involved in the production of dTDP-D-mycaminose . Biochemistry . 50 . 5 . 780–7 . February 2011 . 21142177 . 3079244 . 10.1021/bi101733y .