DTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose N,N-dimethyltransferase explained

DTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose N,N-dimethyltransferase
Ec Number:	2.1.1.234

DTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose N,N-dimethyltransferase (DesVI) is an enzyme with systematic name S-adenosyl-L-methionine:dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose 3-N,N-dimethyltransferase.^{[1] [2]} This enzyme catalyses the following chemical reaction

2 S-adenosyl-L-methionine + dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose

\rightleftharpoons 2 S-adenosyl-L-homocysteine + dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose

The enzyme is involved in the biosynthesis of desosamine.

Notes and References

1. Chen H, Yamase H, Murakami K, Chang CW, Zhao L, Zhao Z, Liu HW . Expression, purification, and characterization of two N,N-dimethyltransferases, tylM1 and desVI, involved in the biosynthesis of mycaminose and desosamine . Biochemistry . 41 . 29 . 9165–83 . July 2002 . 12119032 . 10.1021/bi020245j .
2. Burgie ES, Holden HM . Three-dimensional structure of DesVI from Streptomyces venezuelae: a sugar N,N-dimethyltransferase required for dTDP-desosamine biosynthesis . Biochemistry . 47 . 13 . 3982–8 . April 2008 . 18327916 . 10.1021/bi800063j .