DGTPase explained

dGTPase
Ec Number:	3.1.5.1
Cas Number:	9025-63-2
Go Code:	0008832

The enzyme dGTPase (EC 3.1.5.1)^{[1] [2]} catalyzes the reaction

dGTP + H₂O

\rightleftharpoons deoxyguanosine + triphosphate

This enzyme belongs to the family of hydrolases, specifically those acting on triphosphoric monoester bonds. The systematic name is dGTP triphosphohydrolase. Other names in common use include deoxy-GTPase, deoxyguanosine 5-triphosphate triphosphohydrolase, deoxyguanosine triphosphatase, and deoxyguanosine triphosphate triphosphohydrolase. This enzyme participates in purine metabolism.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes,,, and .

Notes and References

1. Kornberg SR, Lehman IR, Bessman MJ, Simms ES, Kornberg A . 1958 . Enzymatic cleavage of deoxyguanosine triphosphate to deoxyguanosine and tripolyphosphate . J. Biol. Chem. . 233 . 159 - 62 . 13563461 . 1 .
2. Seto D, Bhatnagar SK, Bessman MJ . 1988 . The purification and properties of deoxyguanosine triphosphate triphosphohydrolase from E. coli . J. Biol. Chem. . 263 . 1494 - 99 . 2826481 . 3 .