Cytosine deaminase explained

cytosine deaminase
Ec Number:	3.5.4.1
Cas Number:	9025-05-2
Go Code:	0004131

In enzymology, a cytosine deaminase is an enzyme that catalyzes the chemical reaction

cytosine + H₂O

\rightleftharpoons uracil + NH₃

Thus, the two substrates of this enzyme are cytosine^[1] and H₂O, whereas its two products are uracil and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is cytosine aminohydrolase. This enzyme is also called isocytosine deaminase. This enzyme participates in pyrimidine metabolism.

Structural studies

As of late 2007, 13 structures have been solved for this class of enzymes, with PDB accession codes,,,,,,,,,,,, and .

References

• COHEN SS, BARNER HD . 1957 . The conversion of 5-methyldeoxycytidine to thymidine in vitro and in vivo . J. Biol. Chem. . 226 . 631 - 42 . 13438848 . 2 .
• Kream J . Chargaff E . 1952 . On the cytosine deaminase of yeast . J. Am. Chem. Soc. . 74 . 20 . 5157 - 5160 . 10.1021/ja01140a050 .

Notes and References

1. Sukumar. Uday Kumar. Packirisamy. Gopinath. 2015-08-11. Bioactive Core–Shell Nanofiber Hybrid Scaffold for Efficient Suicide Gene Transfection and Subsequent Time Resolved Delivery of Prodrug for Anticancer Therapy. ACS Applied Materials & Interfaces. EN. 7. 33. 18717–18731. 10.1021/acsami.5b05280. 26234345. 1944-8244.