Cyclin E2 Explained

Cyclin E2 is a protein that in humans is encoded by the CCNE2 gene. It is a G1 cyclin that binds Cdk2 and is inhibited by p27(Kip1) and p21(Cip1).^[1] It plays a role in the G1/S portion of the cell cycle and also has putative interactions with proteins CDKN1A, CDKN1B, and CDK3. Aberrant expression can lead to cancer.^[1]

References

• Zariwala . M. . Liu . J. . Xiong . Y. . 1998-11-26 . Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins . Oncogene . 17 . 21 . 2787–2798 . 10.1038/sj.onc.1202505 . 0950-9232 . 9840943. 7340570 . free .

Notes and References

1. Gudas JM, Payton M, Thukral S, Chen E, Bass M, Robinson MO, Coats S . Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers . Molecular and Cellular Biology . 19 . 1 . 612–22 . January 1999 . 9858585 . 83919 . 10.1128/mcb.19.1.612 .