CCNC (gene) explained

Cyclin-C is a protein that in humans is encoded by the CCNC gene.^{[1] [2]}

The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phosphorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene.

Interactions

CCNC (gene) has been shown to interact with Estrogen receptor alpha^[3] and Cyclin-dependent kinase 8.^{[3] [4] [5] [6] [7]}

Further reading

• Nozawa T, Hatano M, Yamamoto H, Kwan T . Magnetic circular dichroism on the reversible oxygenation of dimethylmesoporphyrin-IX-atopyridinecobalt (II) . Bioinorganic Chemistry . 5 . 3 . 267–73 . 1976 . 1260071 . 10.1016/S0006-3061(00)82025-6 .
• Tassan JP, Jaquenoud M, Léopold P . Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C . Proc. Natl. Acad. Sci. U.S.A. . 92 . 19 . 8871–5 . 1995 . 7568034 . 10.1073/pnas.92.19.8871 . 41069 . etal. 1995PNAS...92.8871T. free .
• Demetrick DJ, Matsumoto S, Hannon GJ . Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3) . Cytogenet. Cell Genet. . 69 . 3–4 . 190–2 . 1995 . 7698009 . 10.1159/000133960 . etal.
• Yoshizumi M, Lee WS, Hsieh CM . Disappearance of cyclin A correlates with permanent withdrawal of cardiomyocytes from the cell cycle in human and rat hearts . J. Clin. Invest. . 95 . 5 . 2275–80 . 1995 . 7738192 . 10.1172/JCI117918 . 295840 . etal.
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Rickert P, Seghezzi W, Shanahan F . Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II . Oncogene . 12 . 12 . 2631–40 . 1996 . 8700522 . etal.
• Li H, Lahti JM, Valentine M . Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors . Genomics . 32 . 2 . 253–9 . 1997 . 8833152 . 10.1006/geno.1996.0112 . etal.
• Cujec TP, Cho H, Maldonado E . The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme . Mol. Cell. Biol. . 17 . 4 . 1817–23 . 1997 . 9121429 . 10.1128/MCB.17.4.1817. 232028 . etal.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Neish AS, Anderson SF, Schlegel BP . Factors associated with the mammalian RNA polymerase II holoenzyme . Nucleic Acids Res. . 26 . 3 . 847–53 . 1998 . 9443979 . 10.1093/nar/26.3.847 . 147327 . etal.
• Cho H, Orphanides G, Sun X . A Human RNA Polymerase II Complex Containing Factors That Modify Chromatin Structure . Mol. Cell. Biol. . 18 . 9 . 5355–63 . 1998 . 9710619 . 10.1128/MCB.18.9.5355. 109120 . etal.
• Sun X, Zhang Y, Cho H . NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription . Mol. Cell . 2 . 2 . 213–22 . 1998 . 9734358 . 10.1016/S1097-2765(00)80131-8 . etal. free .
• Gu W, Malik S, Ito M . A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation . Mol. Cell . 3 . 1 . 97–108 . 1999 . 10024883 . 10.1016/S1097-2765(00)80178-1 . etal. free .
• Ito M, Yuan CX, Malik S . Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators . Mol. Cell . 3 . 3 . 361–70 . 1999 . 10198638 . 10.1016/S1097-2765(00)80463-3 . etal. free .
• Rachez C, Lemon BD, Suldan Z . Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex . Nature . 398 . 6730 . 824–8 . 1999 . 10235266 . 10.1038/19783 . etal. 1999Natur.398..824R . 204992765 .
• Wang G, Cantin GT, Stevens JL, Berk AJ . Characterization of Mediator Complexes from HeLa Cell Nuclear Extract . Mol. Cell. Biol. . 21 . 14 . 4604–13 . 2001 . 11416138 . 10.1128/MCB.21.14.4604-4613.2001 . 87123 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal. 2002PNAS...9916899M . free .
• Sato S, Tomomori-Sato C, Banks CA . Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3 . J. Biol. Chem. . 278 . 17 . 15123–7 . 2003 . 12584197 . 10.1074/jbc.C300054200 . etal. free .
• Ueberham U, Hessel A, Arendt T . Cyclin C expression is involved in the pathogenesis of Alzheimer's disease . Neurobiol. Aging . 24 . 3 . 427–35 . 2003 . 12600719 . 10.1016/S0197-4580(02)00132-X . 12604491 .

Notes and References

1. Lew DJ, Dulic V, Reed SI . Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast . Cell . 66 . 6 . 1197–206 . Oct 1991 . 1833066 . 10.1016/0092-8674(91)90042-W . 12166415 .
2. Web site: Entrez Gene: CCNC cyclin C.
3. Kang . Yun Kyoung . Guermah Mohamed . Yuan Chao-Xing . Roeder Robert G . Mar 2002 . The TRAP/Mediator coactivator complex interacts directly with estrogen receptors α and β through the TRAP220 subunit and directly enhances estrogen receptor function in vitro . . 99 . 5 . 2642–7 . 0027-8424. 11867769 . 10.1073/pnas.261715899 . 2002PNAS...99.2642K . 122401 . free .
4. Zhang . Y . Iratni R. Erdjument-Bromage H. Tempst P. Reinberg D . May 1997 . Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex . Cell . 89 . 3 . 357–64 . 0092-8674. 9150135 . 10.1016/S0092-8674(00)80216-0 . free .
5. Cho . H . Orphanides G. Sun X. Yang X J. Ogryzko V. Lees E. Nakatani Y. Reinberg D . Sep 1998 . A Human RNA Polymerase II Complex Containing Factors That Modify Chromatin Structure . Mol. Cell. Biol. . 18 . 9 . 5355–63 . 0270-7306. 9710619 . 109120 . 10.1128/MCB.18.9.5355 .
6. Wang . G . Cantin G T. Stevens J L. Berk A J . Jul 2001 . Characterization of Mediator Complexes from HeLa Cell Nuclear Extract . Mol. Cell. Biol. . 21 . 14 . 4604–13 . 0270-7306. 11416138 . 10.1128/MCB.21.14.4604-4613.2001 . 87123 .
7. Tassan . J P . Jaquenoud M. Léopold P. Schultz S J. Nigg E A . Sep 1995 . Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C . . 92 . 19 . 8871–5 . 0027-8424. 7568034 . 1995PNAS...92.8871T . 10.1073/pnas.92.19.8871 . 41069 . free .