Cyclin-dependent kinase 3 explained

Cell division protein kinase 3 is an enzyme that in humans is encoded by the CDK3 gene.^{[1] [2]}

Function

CDK3 complements cdc28 mutants of Saccharomyces cerevisiae suggesting that it may be involved in cell cycle control. CDK3 can phosphorylate histone H1 and interacts with an unknown type of cyclin.^[2]

Further reading

• Bullrich F, MacLachlan TK, Sang N . Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer. . Cancer Res. . 55 . 6 . 1199–205 . 1995 . 7882308 . etal.
• Gyuris J, Golemis E, Chertkov H, Brent R . Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2. . Cell . 75 . 4 . 791–803 . 1993 . 8242750 . 10.1016/0092-8674(93)90498-F . free .
• Sasaguri T, Ishida A, Kosaka C . Phorbol ester inhibits the phosphorylation of the retinoblastoma protein without suppressing cyclin D-associated kinase in vascular smooth muscle cells. . J. Biol. Chem. . 271 . 14 . 8345–51 . 1996 . 8626531 . 10.1074/jbc.271.14.8345 . etal. free .
• Meikrantz W, Schlegel R . Suppression of apoptosis by dominant negative mutants of cyclin-dependent protein kinases. . J. Biol. Chem. . 271 . 17 . 10205–9 . 1996 . 8626584 . 10.1074/jbc.271.17.10205 . free .
• Hofmann F, Livingston DM . Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit. . Genes Dev. . 10 . 7 . 851–61 . 1996 . 8846921 . 10.1101/gad.10.7.851 . free .
• Lamphere L, Fiore F, Xu X . Interaction between Cdc37 and Cdk4 in human cells. . Oncogene . 14 . 16 . 1999–2004 . 1997 . 9150368 . 10.1038/sj.onc.1201036 . 25236893 . etal.
• Braun K, Hölzl G, Soucek T . Investigation of the cell cycle regulation of cdk3-associated kinase activity and the role of cdk3 in proliferation and transformation. . Oncogene . 17 . 17 . 2259–69 . 1998 . 9811456 . 10.1038/sj.onc.1202145 . 12470182 . etal.
• Yamochi T, Semba K, Tsuji K . ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3). . Eur. J. Biochem. . 268 . 23 . 6076–82 . 2002 . 11733001 . 10.1046/j.0014-2956.2001.02555.x . etal.
• Sato H, Nishimoto I, Matsuoka M . ik3-2, a relative to ik3-1/cables, is associated with cdk3, cdk5, and c-abl. . Biochim. Biophys. Acta . 1574 . 2 . 157–63 . 2002 . 11955625 . 10.1016/S0167-4781(01)00367-0 .
• Schang LM, Bantly A, Schaffer PA . Explant-induced reactivation of herpes simplex virus occurs in neurons expressing nuclear cdk2 and cdk4 . J. Virol. . 76 . 15 . 7724–35 . 2002 . 12097586 . 10.1128/JVI.76.15.7724-7735.2002 . 136347 .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Ren S, Rollins BJ . Cyclin C/cdk3 promotes Rb-dependent G0 exit . Cell . 117 . 2 . 239–51 . 2004 . 15084261 . 10.1016/S0092-8674(04)00300-9 . 890866 . free .
• Zhang Y, Wolf-Yadlin A, Ross PL . Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules . Mol. Cell. Proteomics . 4 . 9 . 1240–50 . 2005 . 15951569 . 10.1074/mcp.M500089-MCP200 . etal. free .
• Beausoleil SA, Villén J, Gerber SA . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 . etal.
• Olsen JV, Blagoev B, Gnad F . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . etal. free .
• Wissing J, Jänsch L, Nimtz M . Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry . Mol. Cell. Proteomics . 6 . 3 . 537–47 . 2007 . 17192257 . 10.1074/mcp.T600062-MCP200 . 40974821 . etal. free .

Notes and References

1. Meyerson M, Enders GH, Wu CL, Su LK, Gorka C, Nelson C, Harlow E, Tsai LH . A family of human cdc2-related protein kinases . EMBO J . 11 . 8 . 2909–17 . Aug 1992 . 1639063 . 556772 . 10.1002/j.1460-2075.1992.tb05360.x.
2. Web site: Entrez Gene: CDK3 cyclin-dependent kinase 3.