Cyclic 3-hydroxymelatonin explained

Cyclic 3-hydroxymelatonin (3-OHM) is a metabolite of melatonin and an antioxidant more potent than melatonin.[1] It is a non-radical species and does not further propagate the radical chain reaction

It is a footprint product of the reaction between melatonin and hydroxyl radical.[2]

Notes and References

  1. Cyclic-3-hydroxymelatonin (C3HOM), a potent antioxidant, scavenges free radicals and suppresses oxidative reactions. Dun-Xian. Tan. R.. Hardeland. L. C.. Manchester. A.. Galano. R. J.. Reiter. May 11, 2014. Current Medicinal Chemistry. 21. 13. 1557–1565. PubMed. 10.2174/0929867321666131129113146. 24304286.
  2. Cyclic 3-Hydroxymelatonin: A Melatonin Metabolite Generated as a Result of Hydroxyl Radical Scavenging. Dun-Xian. Tan. LucienC.. Manchester. RusselJ.. Reiter. BenjaminF.. Plummer. March 19, 1999. Biological Signals and Receptors. 8. 1–2. 70–74. Silverchair. 10.1159/000014571. 2024-07-03 . 10085465 .

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