Cyclase Explained

A cyclase is an enzyme, almost always a lyase, that catalyzes a chemical reaction to form a cyclic compound. Important cyclase enzymes include:

• Adenylyl cyclase, which forms cyclic AMP from adenosine triphosphate (EC 4.6.1.1)
  • ADCY1
  • ADCY2
  • ADCY3
  • ADCY4
  • ADCY5
  • ADCY6
  • ADCY7
  • ADCY8
  • ADCY9
  • ADCY10
• Guanylyl cyclase, which forms cyclic GMP from guanosine triphosphate (EC 4.6.1.2)
  • GUCY1A2
  • GUCY1A3
  • GUCY1B3
  • Guanylate cyclase 2C
  • Guanylate cyclase 2D
  • Guanylate cyclase 2F
  • NPR1
  • NPR2
• Protein cyclase, a ligase enzyme that produces backbone-cyclised proteins by intramolecular transpeptidation