Coumermycin A1 Explained

Coumermycin A1 is an aminocoumarin.^{[1] [2]} Its main target is the ATPase site of the DNA gyrase GyrB subunit.^[3]

See also

• Chemically induced dimerization

Notes and References

1. Heide L . Genetic engineering of antibiotic biosynthesis for the generation of new aminocoumarins . Biotechnology Advances . 27 . 6 . 1006–1014 . 2009 . 19463934 . 10.1016/j.biotechadv.2009.05.017 .
2. Heide L, Gust B, Anderle C, Li SM . Combinatorial biosynthesis, metabolic engineering and mutasynthesis for the generation of new aminocoumarin antibiotics . Current Topics in Medicinal Chemistry . 8 . 8 . 667–79 . 2008 . 18473891 . 10.2174/156802608784221505 .
3. Vanden Broeck A, McEwen AG, Chebaro Y, Potier N, Lamour V . Structural Basis for DNA Gyrase Interaction with Coumermycin A1 . Journal of Medicinal Chemistry . 62 . 8 . 4225–4231 . April 2019 . 30920824 . 10.1021/acs.jmedchem.8b01928 . free .