Corydaline synthase explained

corydaline synthase
Ec Number:	2.1.1.147
Cas Number:	155807-67-3
Go Code:	0050631

In enzymology, a corydaline synthase is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + palmatine + 2 NADPH + H⁺

\rightleftharpoons S-adenosyl-L-homocysteine + corydaline + 2 NADP⁺

The 4 substrates of this enzyme are S-adenosyl methionine, palmatine, NADPH, and H⁺, whereas its 3 products are S-adenosylhomocysteine, corydaline, and NADP⁺.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:protoberberine 13-C-methyltransferase.

References

• Rueffer M, Bauer W, Zenk MH . 1994 . The formation of corydaline and related alkaloids in Corydalis cava in vivo and in vitro . Can. J. Chem. . 72 . 170 - 175 . 10.1139/v94-026 . free .