Corticotropin-like intermediate peptide explained

pro-opiomelanocortin
Hgncid:	9201
Symbol:	POMC
Entrezgene:	5443
Omim:	176830
Refseq:	NM_000939
Uniprot:	P01189
Chromosome:	2
Arm:	p
Band:	23

Corticotropin-like intermediate [lobe] peptide (CLIP), also known as adrenocorticotropic hormone fragment 18-39 (ACTH(18-39)), is a naturally occurring, endogenous neuropeptide with a docosapeptide structure and the amino acid sequence Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe. CLIP is generated as a proteolyic cleavage product of adrenocorticotropic hormone (ACTH),^{[1] [2]} which in turn is a cleavage product of proopiomelanocortin (POMC).^[3] Its physiological role has been investigated in various tissues,^{[4] [5]} specifically in the central nervous system.^{[6] [7] [8] [9] [10]}

It has been suggested to function as an insulin secretagogue in the pancreas.^[11]

Notes and References

1. Gianoulakis C, Seidah NG, Routhier R, Chrétien M . Biosynthesis and characterization of adrenocorticotropic hormone, alpha-melanocyte-stimulating hormone, and an NH2-terminal fragment of the adrenocorticotropic hormone/beta-lipotropin precursor from rat pars intermedia . The Journal of Biological Chemistry . 254 . 23 . 11903–6 . December 1979 . 10.1016/S0021-9258(19)86402-5 . 227883 . free .
2. Book: Lloyd D. Fricker . Peptide biosynthesis and processing . 25 November 2011 . 24 July 1991 . CRC Press . 978-0-8493-8852-1 . 78.
3. Book: Anthony W. Norman . Gerald Litwack . Hormones . registration . 25 November 2011 . 26 September 1997 . Academic Press . 978-0-12-521441-4 . 12.
4. Marshall JB, Kapcala LP, Manning LD, McCullough AJ . Effect of corticotropin-like intermediate lobe peptide on pancreatic exocrine function in isolated rat pancreatic lobules . The Journal of Clinical Investigation . 74 . 5 . 1886–9 . November 1984 . 6209301 . 425369 . 10.1172/JCI111608 .
5. Zaphiropoulos A, Charnay Y, Vallet P, Constantinidis J, Bouras C . Immunohistochemical distribution of corticotropin-like intermediate lobe peptide (CLIP) immunoreactivity in the human brain . Brain Research Bulletin . 26 . 1 . 99–111 . January 1991 . 1849784 . 10.1016/0361-9230(91)90194-O. 556547 .
6. Book: Shojiro Inoué . Shojiro Inoué . Biology of sleep substances . 25 November 2011 . 1989 . CRC Press . 978-0-8493-4822-8 . 136.
7. Chastrette N, Cespuglio R, Jouvet M . Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 1--Hypnogenic properties of ACTH derivatives . Neuropeptides . 15 . 2 . 61–74 . February 1990 . 1981927 . 10.1016/0143-4179(90)90042-w. 41264103 .
8. Chastrette N, Cespuglio R, Lin YL, Jouvet M . Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 2--Aminergic regulatory processes . Neuropeptides . 15 . 2 . 75–88 . February 1990 . 1964203 . 10.1016/0143-4179(90)90043-x. 13731355 .
9. Grigoriev VV, Petrova LN, Ivanova TA, Gabreliyan AV, Serkova TP . Effect of corticotropin-like intermediate lobe peptide on presynaptic and postsynaptic glutamate receptors and postsynaptic GABA receptors in rat brain . Bulletin of Experimental Biology and Medicine . 147 . 3 . 319–22 . March 2009 . 19529852 . 10.1007/s10517-009-0499-x. 29237407 .
10. Seidenbecher T, Balschun D, Vogel D, Reymann KG . Neuronal transmission of hippocampal CA1 neurones is modulated by corticotropin-like intermediate lobe peptide [CLIP; ACTH(18-39)] . Peptides . 14 . 6 . 1221–4 . 1993 . 8134304 . 10.1016/0196-9781(93)90179-K. 7935999 .
11. Marshall . J. B. . Kapcala . L. P. . Manning . L. D. . McCullough . A. J. . November 1984 . Effect of corticotropin-like intermediate lobe peptide on pancreatic exocrine function in isolated rat pancreatic lobules . The Journal of Clinical Investigation . 74 . 5 . 1886–1889 . 10.1172/JCI111608 . 0021-9738 . 6209301. 425369 .