Corticosteroid side-chain-isomerase explained

corticosteroid side-chain-isomerase
Ec Number:	5.3.1.21
Cas Number:	75139-73-0
Go Code:	0004110

In enzymology, a corticosteroid side-chain-isomerase is an enzyme that catalyzes the chemical reaction

11-deoxycorticosterone

\rightleftharpoons 20-hydroxy-3-oxopregn-4-en-21-al

Hence, this enzyme has one substrate, 11-deoxycorticosterone, and one product, 20-hydroxy-3-oxopregn-4-en-21-al.

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ketoses. The systematic name of this enzyme class is 11-deoxycorticosterone aldose-ketose-isomerase.

References

• Martin KO, Oh SW, Lee HJ, Monder C . 1977 . Studies on 21-3H-labeled corticosteroids: evidence for isomerization of the ketol side chain of 11-deoxycorticosterone by a hamster liver enzyme . Biochemistry . 16 . 3803 - 9 . 901753 . 10.1021/bi00636a013 . 17 .
• Monder C, Martin KO, Bogumil J . 1980 . Presence of epimerase activity in hamster liver corticosteroid side chain isomerase . J. Biol. Chem. . 255 . 7192 - 8 . 7391077 . 15 .