Corticosteroid receptor explained
The corticosteroid receptors are receptors for corticosteroids.[1] Corticosteroid receptors mediate the target organ response to the major products of the adrenal cortex, glucocorticoids (principally cortisol in man), and mineralocorticoids (principally aldosterone). They are members of the intracellular receptor superfamily which is highly evolutionarily conserved, and includes receptors for thyroid hormones, vitamin D, sex steroids, and retinoids. They include the following two nuclear receptors:[2] [3]
There are also membrane corticosteroid receptors, including the membrane glucocorticoid receptors and the membrane mineralocorticoid receptors, which are not well-characterized at present.[4] [5] [6]
Notes and References
- Book: Scott T. Brady. George J. Siegel. Robert Wayne Albers. Donald Lowell Price. Basic Neurochemistry: Principles of Molecular, Cellular and Medical Neurobiology. 2012. Academic Press. 978-0-12-374947-5. 522–.
- Book: Eugenia Wang. D. Stephen Snyder. Handbook of the Aging Brain. 13 August 1998. Academic Press. 978-0-08-053322-3. 22–.
- Book: Hormones, Brain and Behavior, Five-Volume Set. 18 June 2002. Academic Press. 978-0-08-053415-2. 267–.
- Groeneweg FL, Karst H, de Kloet ER, Joëls M . Mineralocorticoid and glucocorticoid receptors at the neuronal membrane, regulators of nongenomic corticosteroid signalling . Mol. Cell. Endocrinol. . 350 . 2 . 299–309 . 2012 . 21736918 . 10.1016/j.mce.2011.06.020 . 23048944 .
- Tasker JG, Di S, Malcher-Lopes R . Minireview: rapid glucocorticoid signaling via membrane-associated receptors . Endocrinology . 147 . 12 . 5549–56 . 2006 . 16946006 . 3280589 . 10.1210/en.2006-0981 .
- Dooley R, Harvey BJ, Thomas W . Non-genomic actions of aldosterone: from receptors and signals to membrane targets . Mol. Cell. Endocrinol. . 350 . 2 . 223–34 . 2012 . 21801805 . 10.1016/j.mce.2011.07.019 . 24630510 .
