List of corticosteroid cyclic ketals explained

This is a list of corticosteroid cyclic ketals, including cyclic ketals (cyclic acetals) of steroidal glucocorticoids and mineralocorticoids. They are almost all C16α,17α cyclic ketals of corticosteroids. One of the most widely used corticosteroid cyclic ketals is triamcinolone acetonide, which is the C16α,17α acetonide (cyclic ketone with acetone) of triamcinolone.^[1]

This list mostly does not include esters of corticosteroid cyclic ketals, which are listed here instead.

Acetonides

Acetonides (cyclic ketals with acetone):

• Cicortonide
• Ciprocinonide (fluocinolone acetonide cyclopropylcarboxylate)
• Descinolone acetonide (desoxytriamcinolone acetonide)
• Desonide (desfluorotriamcinolone acetonide)
• Drocinonide
• Fluclorolone acetonide (flucloronide)
• Fludroxycortide (flurandrenolide, flurandrenolone)
• Flumoxonide
• Flunisolide
• Fluocinolone acetonide
• Fluocinonide (fluocinolone acetonide 21-acetate)
• Flupamesone (triamcinolone acetonide metembonate)
• Formocortal
• Halcinonide
• Procinonide (fluocinolone acetonide propionate)
• Tralonide
• Triamcinolone acetonide
• Triamcinolone benetonide (triamcinolone acetonide 21-(benzoyl-β-aminoisobutyrate))
• Triamcinolone furetonide (triamcinolone acetonide 21-(2-benzofurancarboxylate))
• Triamcinolone hexacetonide (triamcinolone acetonide 21-tebutate)
• Triclonide

Others

Acetophenides

Acetophenides (cyclic ketals with acetophenone):

• Algestone acetophenide (dihydroxyprogesterone acetophenide)
• Amcinafide (triamcinolone acetophenide)

Acroleinides

Acroleinides (cyclic ketals with acrolein):

• Acrocinonide (triamcinolone acroleinide)

Aminobenzals

Aminobenzals (cyclic ketals with 4-dimethylaminobenzylidene):

• Triamcinolone aminobenzal benzamidoisobutyrate (TBI-PAB)

Cyclopentanonides

Cyclopentanonides (cyclic ketals with cyclopentanone):

• Amcinonide (triamcinolone acetate cyclopentanonide)

Pentanonides

Pentanonides (cyclic ketals with 3-pentanone)

• Amcinafal (triamcinolone pentanonide)

With butyraldehyde

Cyclic ketals with butyraldehyde:

• Budesonide
• Dexbudesonide
• Itrocinonide
• Rofleponide

Miscellaneous

• Nicocortonide is a C14α,17α cyclic ketal with crotonaldehyde

See also

• List of corticosteroids
• Steroid ester
• List of corticosteroid esters

Notes and References

1. Book: J. Elks. The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 1228–.