Coronaridine Explained

Coronaridine, also known as 18-carbomethoxyibogamine, is an alkaloid found in Tabernanthe iboga and related species, including Tabernaemontana divaricata for which (under the now obsolete synonym Ervatamia coronaria) it was named.[1]

Like ibogaine, (R)-coronaridine and (S)-coronaridine can decrease intake of cocaine and morphine in animals[2] and it may have muscle relaxant and hypotensive activity.[3]

Chemistry

Congeners

Coronaridine congers are important in drug discovery and development due to multiple actions on different targets. They have ability to inhibit Cav2.2 channel,[4] modulate and inhibit subunits of nAChr selectively such as α9α10,[5] α3β4[6] [7] and potentiate GABAA activity.[8]

Pharmacology

Coronaridine has been reported to bind to an assortment of molecular sites, including: μ-opioid (Ki = 2.0 μM), δ-opioid (Ki = 8.1 μM), and κ-opioid receptors (Ki = 4.3 μM), NMDA receptor (Ki = 6.24 μM) (as an antagonist),[9] and nAChRs (as an antagonist).[10] It has also been found to inhibit the enzyme acetylcholinesterase, act as a voltage-gated sodium channel blocker,[11] and displays estrogenic activity in rodents. In contrast to ibogaine and other iboga alkaloids, coronaridine does not bind to either the σ1 or σ2 receptor.

See also

Notes and References

  1. Delorenzi JC, Freire-de-Lima L, Gattass CR, de Andrade Costa D, He L, Kuehne ME, Saraiva EM . In vitro activities of iboga alkaloid congeners coronaridine and 18-methoxycoronaridine against Leishmania amazonensis . Antimicrobial Agents and Chemotherapy . 46 . 7 . 2111–2115 . July 2002 . 12069962 . 127312 . 10.1128/aac.46.7.2111-2115.2002 .
  2. Book: The Psychopharmacology of Herbal Medicine: Plant Drugs that Alter Mind, Brain, and Behavior. Spinella M . 2001. 978-0262692656 . The MIT Press; Illustrated edition.
  3. Perera P, Kanjanapothy D, Sandberg F, Verpoorte R . Muscle relaxant activity and hypotensive activity of some Tabernaemontana alkaloids . Journal of Ethnopharmacology . 13 . 2 . 165–173 . May 1985 . 4021514 . 10.1016/0378-8741(85)90004-2 .
  4. Arias HR, Tae HS, Micheli L, Yousuf A, Ghelardini C, Adams DJ, Di Cesare Mannelli L . Coronaridine congeners decrease neuropathic pain in mice and inhibit α9α10 nicotinic acetylcholine receptors and CaV2.2 channels . . 175 . 108194 . September 2020 . 32540451 . 10.1016/j.neuropharm.2020.108194 . 2158/1213504 . 219705597 . free .
  5. Arias HR, Tae HS, Micheli L, Yousuf A, Ghelardini C, Adams DJ, Di Cesare Mannelli L . Coronaridine congeners decrease neuropathic pain in mice and inhibit α9α10 nicotinic acetylcholine receptors and CaV2.2 channels . . 175 . 108194 . September 2020 . 32540451 . 10.1016/j.neuropharm.2020.108194 . 2158/1213504 . 219705597 . free .
  6. Arias HR, Targowska-Duda KM, Feuerbach D, Jozwiak K . Coronaridine congeners inhibit human α3β4 nicotinic acetylcholine receptors by interacting with luminal and non-luminal sites . . 65 . 81–90 . August 2015 . 26022277 . 10.1016/j.biocel.2015.05.015 . free .
  7. Arias HR, Lykhmus O, Uspenska K, Skok M . Coronaridine congeners modulate mitochondrial α3β4* nicotinic acetylcholine receptors with different potency and through distinct intra-mitochondrial pathways . . 114 . 26–32 . March 2018 . 29277577 . 10.1016/j.neuint.2017.12.008 . 3675707 .
  8. Arias HR, Do Rego JL, Do Rego JC, Chen Z, Anouar Y, Scholze P, Gonzales EB, Huang R, Chagraoui A . Coronaridine congeners potentiate GABAA receptors and induce sedative activity in mice in a benzodiazepine-insensitive manner . . 101 . 109930 . July 2020 . 32194202 . 10.1016/j.pnpbp.2020.109930 . 212734631 .
  9. Book: Wiart C . Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases. 16 December 2013. Academic Press. 978-0-12-398383-1. 67–69, 73.
  10. Book: Polya G . Biochemical Targets of Plant Bioactive Compounds: A Pharmacological Reference Guide to Sites of Action and Biological Effects. 15 May 2003. CRC Press. 978-0-203-01371-7. 203–.
  11. Book: Popik P, Skolnick P . Pharmacology of Ibogaine and Ibogaine-Related Alkaloids . Cordell GA . The Alkaloids. Chemistry and Biology . 52 . 1999 . Academic Press . San Diego . 978-0-08-086576-8 . 197–232 (222) . https://books.google.com/books?id=bE503LRsawYC&pg=PA22.
  12. Web site: (−)-Coronaridine . ChEBI . European Bioinformatics Institute . CHEBI:3887 .

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Coronaridine".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.