Coriamyrtin Explained

Coriamyrtin is a toxic γ-lactone naturally present in a multitude of plants.

Natural occurrence

Coriamyrtin can be found in Scurrula parasitica,[1] Coriaria microphylla,[2] and certain other plants.

Toxicity

Coriamyrtin is a convulsant.[3] It appears to act via antagonism of GABAA receptors.[4] Poisoning is usually from ingestion of parts of the plants containing it. A case of poisoning was able to be treated with repeated administration of diazepam, an anticonvulsant.[5]

Notes and References

  1. Web site: PubChem . Scurrula parasitica . 2024-02-11 . pubchem.ncbi.nlm.nih.gov . en.
  2. Web site: PubChem . Coriaria microphylla . 2024-02-11 . pubchem.ncbi.nlm.nih.gov . en.
  3. Web site: T3DB: Coriamyrtin . 2024-02-11 . www.t3db.ca.
  4. Pérez . Claudia . Becerra . José . Manríquez-Navarro . Paula . Aguayo . Luis Gerardo . Fuentealba . Jorge . Guzmán . José Leonardo . Joseph-Nathan . Pedro . Jiménez . Verónica . Muñoz . Marcelo Andrés . Silva . Mario . 2011 . Inhibitory activities on mammalian central nervous system receptors and computational studies of three sesquiterpene lactones from Coriaria ruscifolia subsp. ruscifolia . Chemical & Pharmaceutical Bulletin . 59 . 2 . 161–165 . 10.1248/cpb.59.161 . 1347-5223 . 21297293.
  5. de Haro . Luc . Pommier . Philip . Tichadou . Lucia . Hayek-Lanthois . Maryvonne . Arditti . Jocelyne . November 2005 . Poisoning by Coriaria myrtifolia Linnaeus: a new case report and review of the literature . Toxicon. 46 . 6 . 600–603 . 10.1016/j.toxicon.2005.06.026 . 0041-0101 . 16165183. 2005Txcn...46..600D .

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