Conserved oligomeric Golgi complex explained

The conserved oligomeric Golgi complex (COG) is a multiprotein complex found in the Golgi apparatus structure and involved in intracellular transport and glycoprotein modification.^[1]

Earlier names for this complex were: the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and are termed the conserved oligomeric Golgi (COG) complex.^{[2] [3]}

Structure

The COG protein complex consists of eight subunits, in two lobes; Lobe A consists of COG1, COG2, COG3, COG4 and lobe B consists of COG5, COG6, COG7, COG8.^[4]

Function

The conserved oligomeric Golgi complex plays important roles in maintaining structure and transport mechanisms within the Golgi apparatus.

External links

• Role of the conserved oligomeric Golgi (COG) complex in protein glycosylation. Smith & Lupashin. 2008
• The conserved oligomeric Golgi complex is required for fucosylation of N-glycans in Caenorhabditis elegans. 2012

Notes and References

1. Ungar D, Oka T, Brittle EE, Vasile E, Lupashin VV, Chatterton JE, Heuser JE, Krieger M, Waters MG . Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function . J Cell Biol . 157 . 3 . 405–15 . Apr 2002 . 11980916 . 2173297 . 10.1083/jcb.200202016 .
2. Web site: Entrez Gene: COG5 component of oligomeric golgi complex 5.
3. Ungar et al., 2002)
4. 18353293 . 10.1016/j.carres.2008.01.034 . 2773262 . 343 . 12 . Role of the conserved oligomeric Golgi (COG) complex in protein glycosylation . 2008 . Carbohydr Res . 2024–31 . Smith RD, Lupashin VV.