Connective tissue nevus explained

Connective tissue nevus
Synonyms:Collagenoma, Elastoma, and Shagreen patch[1]
Field:Dermatology

A connective tissue nevus is a skin lesion which may be present at birth or appear within the first few years of life. It is elevated, soft to firm in consistency, varying in size from 0.5 to several centimeters in diameter, and may manifest as grouped, linear, or irregularly-distributed lesions.[2]

Signs and symptoms

Connective tissue nevi are thickened regions of skin that look as a series of skin-colored papules and plaques. The spots will become discolored in a yellowish manner as the skin covering them is stretched. Occasionally, they could seem red and have enhanced vascularity.[3]

Causes

The majority of reports are of random lesions, but there are some familial cases, indicating autosomal dominant transmission.[4] [5] Furthermore, connective tissue nevus can present as solitary lesions or be a component of systemic illnesses like tuberous sclerosis, which features shagreen's patches, another form of collagenoma, as an associated feature, or Buschke–Ollendorff syndrome, which is linked to collagenomas and elastomas.[6] [7]

Diagnosis

In addition to hematoxylin-eosin staining to evaluate histological changes, lesion characteristics, genetic history, and special histochemical staining to highlight the composition of connective tissue nevus for differentiation, these tests are necessary for the diagnosis of connective tissue nevus.[8]

See also

Further reading

External links

Notes and References

  1. Book: Rapini, Ronald P. . Bolognia, Jean L. . Jorizzo, Joseph L. . Dermatology: 2-Volume Set . Mosby . St. Louis . 2007 . 978-1-4160-2999-1 .
  2. Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. .
  3. Book: Weston, William L. . Lane . Alfred T. . Morelli . Joseph G. . Color Textbook of Pediatric Dermatology . Skin Diseases in Newborns . Elsevier . 2007 . 10.1016/b978-0-323-04909-2.50024-2 . 381–411.
  4. Saussine . Anne . Marrou . Karine . Delanoé . Phillippe . Bodak . Nathalie . Hamel . Dominique . Picard . Arnaud . Sassolas . Bruno . de Prost . Yves . Lemerrer . Martine . Fraitag . Sylvie . Bodemer . Christine . Connective tissue nevi: An entity revisited . Journal of the American Academy of Dermatology . Elsevier BV . 67 . 2 . 2012 . 0190-9622 . 10.1016/j.jaad.2011.08.008 . 233–239.
  5. McCuaig . Catherine C. . Vera . Caridad . Kokta . Victor . Marcoux . Danielle . Hatami . Afshin . Thuraisingam . Thusanth . Marton . Dominique . Fortier-Riberdy . Geneviève . Powell . Julie . Connective tissue nevi in children: Institutional experience and review . Journal of the American Academy of Dermatology . Elsevier BV . 67 . 5 . 2012 . 0190-9622 . 10.1016/j.jaad.2012.01.036 . 890–897.
  6. Pope . V. . Dupuis . L. . Kannu . P. . Mendoza-Londono . R. . Sajic . D. . So . J. . Yoon . G. . Lara-Corrales . I. . Buschke–Ollendorff syndrome: a novel case series and systematic review . British Journal of Dermatology . Oxford University Press (OUP) . 174 . 4 . 2016-03-08 . 0007-0963 . 10.1111/bjd.14366 . 723–729.
  7. Arora . Harleen . Falto-Aizpurua . Leyre . Cortés-Fernandez . Andrea . Choudhary . Sonal . Romanelli . Paolo . Connective Tissue Nevi: A Review of the Literature . The American Journal of Dermatopathology . Ovid Technologies (Wolters Kluwer Health) . 39 . 5 . 2017 . 0193-1091 . 10.1097/dad.0000000000000638 . 325–341.
  8. Yang . Qingqing . Liu . Shengxiu . Connective tissue nevus—Isolated collagenoma . Skin Research and Technology . Wiley . 28 . 6 . 2022-10-25 . 0909-752X . 10.1111/srt.13210 . 880–881. 9907574 .

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