Concentrative nucleoside transporter 1 explained

Concentrative nucleoside transporter 1 (CNT1) is a protein that in humans is encoded by the SLC28A1 gene.^{[1] [2]}

See also

• Concentrative nucleoside transporters
• Nucleoside transporters
• Solute carrier family

Further reading

• Ritzel MW, Ng AM, Yao SY . Recent molecular advances in studies of the concentrative Na+-dependent nucleoside transporter (CNT) family: identification and characterization of novel human and mouse proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib). . Mol. Membr. Biol. . 18 . 1 . 65–72 . 2001 . 11396613 . 10.1080/09687680118530 . 218896128 . etal.
• Ritzel MW, Yao SY, Ng AM . Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine. . Mol. Membr. Biol. . 15 . 4 . 203–11 . 1999 . 10087507 . 10.3109/09687689709044322 . etal. free .
• Loewen SK, Ng AM, Yao SY . Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2. . J. Biol. Chem. . 274 . 35 . 24475–84 . 1999 . 10455109 . 10.1074/jbc.274.35.24475 . etal. free .
• Mata JF, García-Manteiga JM, Lostao MP . Role of the human concentrative nucleoside transporter (hCNT1) in the cytotoxic action of 5[Prime]-deoxy-5-fluorouridine, an active intermediate metabolite of capecitabine, a novel oral anticancer drug. . Mol. Pharmacol. . 59 . 6 . 1542–8 . 2001 . 11353816 . 10.1124/mol.59.6.1542. etal. 10171/21116 . free .
• Lai Y, Bakken AH, Unadkat JD . Simultaneous expression of hCNT1-CFP and hENT1-YFP in Madin-Darby canine kidney cells. Localization and vectorial transport studies. . J. Biol. Chem. . 277 . 40 . 37711–7 . 2002 . 12097333 . 10.1074/jbc.M204986200 . free .
• Alcorn J, Lu X, Moscow JA, McNamara PJ . Transporter gene expression in lactating and nonlactating human mammary epithelial cells using real-time reverse transcription-polymerase chain reaction. . J. Pharmacol. Exp. Ther. . 303 . 2 . 487–96 . 2002 . 12388627 . 10.1124/jpet.102.038315 . 16195525 .
• Molina-Arcas M, Bellosillo B, Casado FJ . Fludarabine uptake mechanisms in B-cell chronic lymphocytic leukemia. . Blood . 101 . 6 . 2328–34 . 2003 . 12411296 . 10.1182/blood-2002-07-2236 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . etal. free .
• García-Manteiga J, Molina-Arcas M, Casado FJ . Nucleoside transporter profiles in human pancreatic cancer cells: role of hCNT1 in 2',2'-difluorodeoxycytidine- induced cytotoxicity. . Clin. Cancer Res. . 9 . 13 . 5000–8 . 2004 . 14581375 . etal.
• Loewen SK, Yao SY, Slugoski MD . Transport of physiological nucleosides and anti-viral and anti-neoplastic nucleoside drugs by recombinant Escherichia coli nucleoside-H(+) cotransporter (NupC) produced in Xenopus laevis oocytes. . Mol. Membr. Biol. . 21 . 1 . 1–10 . 2004 . 14668133 . 10.1080/0968768031000140836 . 11973712 . etal. free .
• Gray JH, Mangravite LM, Owen RP . Functional and genetic diversity in the concentrative nucleoside transporter, CNT1, in human populations. . Mol. Pharmacol. . 65 . 3 . 512–9 . 2004 . 14978229 . 10.1124/mol.65.3.512 . 1788715 . etal.
• Farré X, Guillén-Gómez E, Sánchez L . Expression of the nucleoside-derived drug transporters hCNT1, hENT1 and hENT2 in gynecologic tumors. . Int. J. Cancer . 112 . 6 . 959–66 . 2004 . 15386342 . 10.1002/ijc.20524 . 33828164 . etal. free .
• Lai Y, Lee EW, Ton CC . 27633580 . Conserved residues F316 and G476 in the concentrative nucleoside transporter 1 (hCNT1) affect guanosine sensitivity and membrane expression, respectively. . Am. J. Physiol., Cell Physiol. . 288 . 1 . C39–45 . 2005 . 15456697 . 10.1152/ajpcell.00192.2004 . etal.
• Fernández-Veledo S, Jover R, Casado FJ . Transcription factors involved in the expression of SLC28 genes in human liver parenchymal cells. . Biochem. Biophys. Res. Commun. . 353 . 2 . 381–8 . 2007 . 17187757 . 10.1016/j.bbrc.2006.12.021 . etal.
• Slugoski MD, Loewen SK, Ng AM . Specific mutations in transmembrane helix 8 of human concentrative Na+/nucleoside cotransporter hCNT1 affect permeant selectivity and cation coupling. . Biochemistry . 46 . 6 . 1684–93 . 2007 . 17279631 . 10.1021/bi061692s . etal.
• Smith KM, Slugoski MD, Cass CE . Cation coupling properties of human concentrative nucleoside transporters hCNT1, hCNT2 and hCNT3. . Mol. Membr. Biol. . 24 . 1 . 53–64 . 2007 . 17453413 . 10.1080/09687860600942534 . 20779608 . etal.
• Guallar JP, Cano-Soldado P, Aymerich I . Altered expression of nucleoside transporter genes (SLC28 and SLC29) in adipose tissue from HIV-1-infected patients. . Antivir. Ther. (Lond.) . 12 . 6 . 853–63 . 2007 . 10.1177/135965350701200601 . 17926640 . 19447232 . etal. free .

Notes and References

1. Ritzel MW, Yao SY, Huang MY, Elliott JF, Cass CE, Young JD . Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1) . Am J Physiol . 272 . 2 Pt 1 . C707–14 . Apr 1997 . 9124315 . 10.1152/ajpcell.1997.272.2.C707.
2. Web site: Entrez Gene: SLC28A1 solute carrier family 28 (sodium-coupled nucleoside transporter), member 1.