Concentrative nucleoside transporter explained

Symbol:Nucleos_tra2_C
Nucleos_tra2_C
Pfam:PF07662
Interpro:IPR011657
Tcdb:2.A.41
Opm Family:388
Opm Protein:3tij

Human concentrative nucleoside transporters include SLC28A1, SLC28A2 and SLC28A3 proteins. SLC28A2 is a purine-specific Na+-nucleoside cotransporter localised to the bile canalicular membrane.[1] SLC28A1 is a Na+-dependent nucleoside transporter selective for pyrimidine nucleosides and adenosine. It also transports the anti-viral nucleoside analogues Zidovudine and Zalcitabine.[2]

Notes and References

  1. Che M, Ortiz DF, Arias IM . Primary structure and functional expression of a cDNA encoding the bile canalicular, purine-specific Na(+)-nucleoside cotransporter . The Journal of Biological Chemistry . 270 . 23 . 13596–9 . Jun 1995 . 7775409 . 10.1074/jbc.270.23.13596 . free .
  2. Huang QQ, Yao SY, Ritzel MW, Paterson AR, Cass CE, Young JD . Cloning and functional expression of a complementary DNA encoding a mammalian nucleoside transport protein . The Journal of Biological Chemistry . 269 . 27 . 17757–60 . Jul 1994 . 10.1016/S0021-9258(17)32370-0 . 8027026 . free .

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