Combretastatin B-1 Explained

Combretastatin B-1 is a combretastatin and a dihydrostilbenoid. It can be found in Combretum afrum, the Eastern Cape South African bushwillow tree^[1] or in Combretum kraussii, the forest bushwillow.^[2]

It can be produced by selective hydrogenation of combretastatin A-1.^[1]

It is a potent inhibitor of microtubule assembly in vitro.^[1]

Notes and References

1. Pettit . G. R. . Singh . S. B. . Niven . M. L. . Hamel . E. . Schmidt . J. M. . Isolation, Structure, and Synthesis of Combretastatins A-1 and B-1, Potent New Inhibitors of Microtubule Assembly, Derived from Combretum caffrum . 10.1021/np50049a016 . Journal of Natural Products . 50 . 1 . 119–131 . 1987 . 3598594.
2. Uteroactive constituents from Combretum kraussii . Bridget K Brookes, Olga V Doudoukina, Lynn C Katsoulis and Joy H D Veale . South African Journal of Chemistry . 1999 . 52 . 4 . 127 . https://web.archive.org/web/20140808063208/http://connection.ebscohost.com/c/articles/2910831/uteroactive-constituents-from-combretum-kraussii . 8 August 2014 .