Columbamine is a chemical with the molecular formula . It is an organic heterotetracyclic compound and a berberine alkaloid. Columbamine can be also called dehydroisocorypalmine.[1] It has a molecular weight of 338.4 g/mol and its monoisotopic mass is 339.1470581677 daltons.[2] Columbamine is soluble in DMSO[3] and is a solid at room temperature.
Columbamine has been found in Plumeria rubra.