Colterol Explained

Iupac Name:4-[2-(''tert''-Butylamino)-1-hydroxyethyl]benzene-1,2-diol
Cas Number:18866-78-9
Unii:1WH11068UO
Pubchem:25104
Chemspiderid:23451
Synonyms:N-tert-Butylarterenol; N-tert-Butylnoradrenaline
C:12
H:19
N:1
O:3
Stdinchi:1S/C12H19NO3/c1-12(2,3)13-7-11(16)8-4-5-9(14)10(15)6-8/h4-6,11,13-16H,7H2,1-3H3
Stdinchikey:PHSMOUBHYUFTDM-UHFFFAOYSA-N
Smiles:CC(C)(C)NCC(C1=CC(=C(C=C1)O)O)O

Colterol is a short-acting β2-adrenoreceptor agonist. Bitolterol, a prodrug for colterol,[1] is used in the management of bronchospasm in asthma and chronic obstructive pulmonary disease (COPD).

Patents:[2] [3]

Notes and References

  1. Walker SB, Kradjan WA, Bierman CW . Bitolterol mesylate: a beta-adrenergic agent. Chemistry, pharmacokinetics, pharmacodynamics, adverse effects and clinical efficacy in asthma . Pharmacotherapy . 5 . 3 . 127–37 . 6 May 1985 . 3895171 . 10.1002/j.1875-9114.1985.tb03410.x . 29431526 .
  2. Aktiengesellschaft F Hoffmann, CH263801 (1949-09-15 to Hoffmann La Roche).
  3. Yasuo Konishi, Joanne Magoon, Suwatchai Jarussophon, WO2008092257 (2008 to National Research Council Of Canada). Location in patent: Page column 17.