Collagenous fibroma explained

Collagenous fibroma, also known as desmoplastic fibroblastoma, is a slow-growing, deep-set, benign fibrous tumor, usually located in the deep subcutis, fascia, aponeurosis, or skeletal muscle of the extremities, limb girdles, or head and neck regions.[1] The World Health Organization in 2020 reclassified desmoplastic fibroblastoma/collagenous fibroma as a specific benign tumor type within the broad category of fibroblastic and myofibroblastic tumors.[2]

Signs and symptoms

Clinically, the lesion is observed as a hard, well-circumscribed, lobulated, round to oval, or fibrous mass that has a sparkling gray-to-white aspect and appears fibrous on the cut surface.[3] Patients with these tumors often appear with a history of a painless, slowly developing mass, often over a reasonably lengthy period of time. These tumors are mostly found in the subcutaneous and skeletal muscle tissues of the extremities.[4] These tumors usually have a diameter of 1 to 20 cm, with a median diameter of 3 cm.[5] [6]

Diagnosis

Collagenous fibroma is characterized histopathologically by long, sweeping fascicles of uniformly spindled cells that range in size from moderately to hypercellular. Long, thick-walled arteries exhibiting perivascular stromal edema are seen.[7] Gardner fibroma, nuchal-type fibroma, and desmoid tumor are examples of differential diagnoses.[8]

The fibroblastic cells have strong vimentin immunohistochemistry.[9] A small number of cells may exhibit positive immunoreactivity for alpha-smooth muscle actin and muscle-specific proteins.[6] The cells resemble fibroblasts or myofibroblasts in terms of ultrastructure.[5]

Treatment

Patients with collagenous fibroma who undergo marginal excision have good surgical results.[10] Video-assisted surgery has been suggested as a substitute for traditional open surgery in the removal of tumors on the chest wall because it minimizes tissue damage and allows for a smaller incision.[11] [12]

See also

Further reading

External links

Notes and References

  1. Book: James, William D. . Andrews' diseases of the skin: clinical dermatology . Berger . Timothy G. . Elston . Dirk M. . Odom . Richard B. . 2006 . Saunders Elsevier . 978-0-7216-2921-6 . 10 . Philadelphia . ocm62736861.
  2. Sbaraglia M, Bellan E, Dei Tos AP . The 2020 WHO Classification of Soft Tissue Tumours: news and perspectives . Pathologica . 113 . 2 . 70–84 . April 2021 . 33179614 . 8167394 . 10.32074/1591-951X-213 .
  3. Hasegawa . T . Shimoda . T . Hirohashi . S . Hizawa . K . Sano . T . Collagenous fibroma (desmoplastic fibroblastoma): report of four cases and review of the literature . Archives of Pathology & Laboratory Medicine . May 1998 . 122 . 5 . 455–460 . 9593348.
  4. Gong . Li-Hua . Liu . Wei-Feng . Ding . Yi . Geng . Yue-Hang . Sun . Xiao-Qi . Huang . Xiao-Yuan . Diagnosis and Differential Diagnosis of Desmoplastic Fibroblastoma by Clinical, Radiological, and Histopathological Analyses . Chinese Medical Journal . Ovid Technologies (Wolters Kluwer Health) . 131 . 1 . 2018-01-05 . 0366-6999 . 10.4103/0366-6999.221274 . free . 32–36. 29271377 . 5754955 .
  5. Harry . Evans . Desmoplastic fibroblastoma. A report of seven cases . The American Journal of Surgical Pathology . September 1995 . 19 . 9 . 1077–1081 . 10.1097/00000478-199509000-00012 . 7661281 . 20 April 2024.
  6. Miettinen . Markku . Fetsch . John F . Collagenous fibroma (desmoplastic fibroblastoma): A clinicopathologic analysis of 63 cases of a distinctive soft tissue lesion with stellate-shaped fibroblasts . Human Pathology . Elsevier BV . 29 . 7 . 1998 . 0046-8177 . 10.1016/s0046-8177(98)90275-1 . 676–682. 9670823 .
  7. Bakhshwin . Ahmed . Oaxaca . Gabriel . Armstrong . Susan . Ko . Jennifer . Billings . Steven . Superficial desmoplastic fibroblastoma (collagenous fibroma): Clinicopathologic study of 11 cases . Journal of Cutaneous Pathology . Wiley . 51 . 1 . 2023-09-04 . 0303-6987 . 10.1111/cup.14529 . 70–75. 37666661 . free .
  8. Osipov . Vladimir . Carrera . Guillermo F. . Collagenous Fibroma (Desmoplastic Fibroblastoma) with Vertebral Body Erosion . Sarcoma . Hindawi Limited . 2009 . 2009 . 1357-714X . 10.1155/2009/682687 . free . 1–3. 19503798 . 2688648 .
  9. Bhagalia . Sanjay . Jain . Manish . Pardhe . Nilesh . Sireesha . SundaragiriKrishna . Collagenous fibroma (desmoplastic fibroblastoma) of the oral cavity . Journal of Oral and Maxillofacial Pathology . Medknow . 16 . 2 . 2012 . 277–279 . 0973-029X . 10.4103/0973-029x.99089 . free . 22923904 . 3424948 .
  10. Nakayama . Shizuhide . Nishio . Jun . Aoki . Mikiko . Nabeshima . Kazuki . Yamamoto . Takuaki . An Update on Clinicopathological, Imaging and Genetic Features of Desmoplastic Fibroblastoma (Collagenous Fibroma) . In Vivo . 35 . 1 . 2021 . 0258-851X . 33402451 . 7880796 . 10.21873/invivo.12233 . 69–73.
  11. Giaccone . Agnese . Solli . Piergiorgio . Pardolesi . Alessandro . Brandolini . Jury . Bertolaccini . Luca . Video-assisted thoracoscopic surgery en bloc chest wall resection . Journal of Visualized Surgery . AME Publishing Company . 3 . 2017-05-26 . 2221-2965 . 10.21037/jovs.2017.04.04 . free . 73. 29078636 . 5637527 .
  12. Ota . Hideki . Ishida . Hirotaka . Matsumoto . Hidekazu . Ishiyama . Tomoharu . An extremely rare case of desmoplastic fibroblastoma exhibiting rapid growth in the chest wall: a case report . Surgical Case Reports . 7 . 1 . 2021 . 2198-7793 . 33829348 . 8026786 . 10.1186/s40792-021-01171-1 . free . 86.

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