Collagen-induced arthritis explained

Collagen-induced arthritis (CIA) is a condition induced in mice (or rats) to study rheumatoid arthritis.^[1]

CIA is induced in mice by injecting them with an emulsion of complete Freund's adjuvant and type II collagen.^[2]

In rats, only one injection is needed, but mice are normally injected twice.^[3]

Further reading

• Julia J. . Inglis . Gabriel. Criado. Mino . Medghalchi. Melanie. Andrews . Collagen-induced arthritis in C57BL/6 mice is associated with a robust and sustained T-cell response to type II collagen . Arthritis Research & Therapy . 29 October 2007 . 1478-6354 . R113 . 9 . 5 . 17967186 . 2212575 . 10.1186/ar2319 . Ann . Sandison . Marc . Feldmann. Richard O.. Williams . none . free.
• K. M. . Pietrosimone . M.. Jin . B. . Poston . P. . Liu . Collagen-Induced Arthritis: A model for Murine Autoimmune Arthritis . Bio-Protocol. 20 October 2015 . 2331-8325 . e1626 . 5 . 20 . 26539560 . 4629450 . 10.21769/bioprotoc.1626 . free . none.
• Rikard . Holmdahl . Robert . Bockermann . Johan . Bäcklund . Hisakata . Yamada . The molecular pathogenesis of collagen-induced arthritis in mice—a model for rheumatoid arthritis . Ageing Research Reviews . 1 February 2002 . 1568-1637 . 135–147 . 1 . 1 . 10.1016/S0047-6374(01)00371-2 . 12039453 . 28243127 . none. subscription .

Notes and References

1. Book: 15064442 . 10.1385/1-59259-771-8:207 . 98 . Collagen-induced arthritis as a model for rheumatoid arthritis . 2004 . Methods Mol Med . 207–16 . Williams . RO. Tumor Necrosis Factor . 978-1-59259-771-0 .
2. 17546023 . 10.1038/nprot.2007.173 . 2 . 5 . Collagen-induced arthritis . 2007 . Nat Protoc . 1269–75 . Brand . DD . Latham . KA . Rosloniec . EF. free .
3. http://ard.bmj.com/content/55/8/535.full.pdf Arthritis in mice induced by a single immunisation with collagen