Colforsin daropate explained

Colforsin daropate is a carboxylic ester derived from the condensation of forskolin (colforsin) with N,N-dimethyl-β-alanine.[1]

Its water-soluble hydrochloride salt (NKH 477)[2] is an adenylyl cyclase activator which has been studied for its cardiac selectivity.[3] [4]

Notes and References

  1. Web site: colforsin daropate . ChEBI . EMBL-EBI . 6 January 2022.
  2. Web site: β-Alanine, N,N-dimethyl-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl ester, hydrochloride (1:1) ]. CAS Common Chemistry . American Chemical Society . 6 January 2022.
  3. Mori M, Takeuchi M, Takaoka H, Hata K, Hayashi Y, Yokoyama M . Effect of NKH477, a new water-soluble forskolin derivative, on arterial-ventricular coupling and mechanical energy transduction in patients with left ventricular systolic dysfunction: comparison with dobutamine . J. Cardiovasc. Pharmacol. . 24 . 2 . 310–6 . August 1994 . 7526066 . 10.1097/00005344-199424020-00018.
  4. Sanbe A, Takeo S . Effects of NKH477, a water-soluble forskolin derivative, on cardiac function in rats with chronic heart failure after myocardial infarction . J. Pharmacol. Exp. Ther. . 274 . 1 . 120–6 . July 1995 . 7616388 .

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