Coenzyme gamma-F420-2:alpha-L-glutamate ligase explained

Coenzyme gamma-F420-2:α-L-glutamate ligase
Ec Number:	6.3.2.32

Coenzyme gamma-F₄₂₀-2:α-L-glutamate ligase (MJ1001, CofF protein, gamma-F420-2:alpha-L-glutamate ligase) is an enzyme with systematic name L-glutamate:coenzyme gamma-F420-2 (ADP-forming).^[1] This enzyme catalyses the following chemical reaction

\rightleftharpoons ADP + phosphate + coenzyme α-F₄₂₀-3

The enzyme caps the γ-glutamyl tail of the hydride carrier coenzyme F₄₂₀.

Notes and References

1. Li H, Xu H, Graham DE, White RH . Glutathione synthetase homologs encode alpha-L-glutamate ligases for methanogenic coenzyme F420 and tetrahydrosarcinapterin biosyntheses . Proceedings of the National Academy of Sciences of the United States of America . 100 . 17 . 9785–90 . August 2003 . 12909715 . 187843 . 10.1073/pnas.1733391100 . free .