Codeine-6-glucuronide explained

Codeine-6-glucuronide (C6G) is a major active metabolite of codeine and may be responsible for as much as 60% of the analgesic effects of codeine. C6G exhibits decreased immunosuppressive effects compared to codeine.[1] During its metabolism, codeine is conjugated with glucuronic acid by the enzyme UDP-Glucuronosyltransferase-2B7 (UGT2B7) to form codeine-6-glucuronide.[2] [3]

See also

Notes and References

  1. Srinivasan . V. . Wielbo . D. . Tebbett . I. R. . Analgesic effects of codeine-6-glucuronide after intravenous administration . European Journal of Pain . 1 . 3 . 185–190 . 1997 . 15102399 . 10.1016/S1090-3801(97)90103-8. 23099329 .
  2. Vree . T. B. . Van Dongen . R. T. . Koopman-Kimenai . P. M. . Codeine analgesia is due to codeine-6-glucuronide, not morphine . International Journal of Clinical Practice . 54 . 6 . 395–398 . 2000 . 10.1111/j.1742-1241.2000.tb11929.x . 11092114. 8281493 .
  3. Armstrong . S. C. . Cozza . K. L. . 10.1176/appi.psy.44.6.515 . Pharmacokinetic Drug Interactions of Morphine, Codeine, and Their Derivatives: Theory and Clinical Reality, Part II . Psychosomatics . 44 . 6 . 515–520 . 2003 . 14597688 . free .

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