Coclaurine Explained

Coclaurine is a nicotinic acetylcholine receptor antagonist^[1] which has been isolated from a variety of plant sources including Nelumbo nucifera, Sarcopetalum harveyanum,^[2] Ocotea duckei,^[3] and others. It belongs to the class of tetrahydroisoquinoline alkaloids. Dimerization of coclaurine leads to the alkaloids such as cepharanthine.

Notes and References

1. https://www.researchgate.net/profile/Matthew_Cheesman4/publication/303689274_Oceania_Antidepressant_Medicinal_Plants/links/5aa85083a6fdcc1b59c63bda/Oceania-Antidepressant-Medicinal-Plants.pdf
2. . 1972 . 35 . 1 . 90–91 . The isolation of stepharine and coclaurine from Sarcopetalum harveyanum . Sowemimo BO, Beal JL, Doskotch RW, Svoboda GH . 5037484.
3. Biochemical Systematics and Ecology . 30 . 9 . 2002 . 881–883 . Coclaurine from Ocotea duckei . I.G da Silva . J.M Barbosa-Filho . M.S da Silva . C.D.G de Lacerda . E.V.L da-Cunha . 10.1016/s0305-1978(02)00024-8. 2002BioSE..30..881D .