Cobalt-factor II C20-methyltransferase explained

cobalt-factor II C20-methyltransferase
Ec Number:	2.1.1.151
Go Code:	0043781

In enzymology, a cobalt-factor II C20-methyltransferase is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + cobalt-factor II

\rightleftharpoons S-adenosyl-L-homocysteine + cobalt-factor III

The two substrates of this enzyme are S-adenosyl methionine and cobalt-factor II; its two products are S-adenosylhomocysteine and cobalt-factor III.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:cobalt-factor-II C20-methyltransferase. This enzyme is also called CbiL. This enzyme is part of the biosynthetic pathway to cobalamin (vitamin B₁₂) in anaerobic bacteria such as Salmonella typhimurium and Bacillus megaterium.

See also

• Cobalamin biosynthesis

References

• Spencer P, Stolowich NJ, Sumner LW, Scott AI . 1998 . Definition of the redox states of cobalt-precorrinoids: investigation of the substrate and redox specificity of CbiL from Salmonella typhimurium . Biochemistry . 37 . 14917 - 27 . 9778368 . 10.1021/bi981366f . 42 .