Clovibactin Explained

Drug Name:

Clovibactin

Width:

300

C:

43

H:

70

N:

10

O:

11

Iupac Name:

(3S,6S,9S,13R)-12-(2S)-2-(2R)-6-amino-2-(2R)-2-(2S)-2-amino-3-phenylpropanoylamino]-4-methylpentanoylamino]hexanoylamino]-3-hydroxypropanoylamino]-9-methyl-3,6-bis(2-methylpropyl)-2,5,8,11-tetraoxo-1-oxa-4,7,10-triazacyclotridecane-13-carboxamide| CAS_number = 2247194-77-8| ChemSpiderID = | PubChem = 142449498| UNII = | ChEBI = | ChEMBL =| smiles = CC(C)C[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](CO)C(=O)NC1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O[C@H]1C(N)=O| StdInChI=1S/C43H70N10O11/c1-22(2)17-29-40(60)51-31(19-24(5)6)43(63)64-34(35(46)55)33(42(62)47-25(7)36(56)49-29)53-41(61)32(21-54)52-38(58)28(15-11-12-16-44)48-39(59)30(18-23(3)4)50-37(57)27(45)20-26-13-9-8-10-14-26/h8-10,13-14,22-25,27-34,54H,11-12,15-21,44-45H2,1-7H3,(H2,46,55)(H,47,62)(H,48,59)(H,49,56)(H,50,57)(H,51,60)(H,52,58)(H,53,61)/t25-,27-,28+,29-,30+,31-,32-,33?,34+/m0/s1| StdInChIKey = SMQAHGKBWXPEHB-MJGFNNBQSA-N}}

Clovibactin (Novo29) is an experimental antibiotic isolated from an uncultured soil Gram-negative β-proteobacterium Eleftheria terrae ssp. carolina, which is one of many soil bacteria.^{[1] [2]}

See also

• Teixobactin
• Zosurabalpin

References

Notes and References

1. Shukla R, Peoples AJ, Ludwig KC, Maity S, Derks MG, de Benedetti S, Krueger AM, Vermeulen BJ, Harbig T, Lavore F, Kumar R, Honorato RV, Grein F, Nieselt K, Liu Y, Bonvin A, Baldus M, Kubitscheck U, Breukink E, Achorn C, Nitti A, Schwalen CJ, Spoering AL, Ling LL, Hughes D, Lelli M, Roos WH, Lewis K, Schneider T, Weingarth M . 6 . An antibiotic from an uncultured bacterium binds to an immutable target . Cell . 186. 19. August 22, 2023 . 4059–4073.e27 . 37611581. 10.1016/j.cell.2023.07.038 . free . 2158/1352736 . free . Preprint:
   Shukla R, Peoples AJ, Ludwig KC, Maity S, Derks MG, de Benedetti S, Krueger AM, Vermeulen BJ, Lavore F, Honorato RV, Grein F, Bonvin A, Kubitscheck U, Breukink E, Achorn C, Nitti A, Schwalen CJ, Spoering AL, Ling LL, Hughes D, Lelli M, Roos WH, Lewis K, Schneider T, Weingarth M . 6 . A new antibiotic from an uncultured bacterium binds to an immutable target . bioRxiv . May 2023 . 37292624 . 10245560 . 10.1101/2023.05.15.540765 .
2. Krumberger M, Li X, Kreutzer AG, Peoples AJ, Nitti AG, Cunningham AM, Jones CR, Achorn C, Ling LL, Hughes DE, Nowick JS . 6 . Synthesis and Stereochemical Determination of the Peptide Antibiotic Novo29 . The Journal of Organic Chemistry . 88 . 4 . 2214–2220 . February 2023 . 36655882 . 9942206 . 10.1021/acs.joc.2c02648 .