Clopimozide Explained

Clopimozide (R-29,764) is a typical antipsychotic drug of the diphenylbutylpiperidine class.^{[1] [2]} It is very potent and has an extremely long duration of action, lasting at least one week with a single dose.^{[3] [4] [5]} It was developed by Janssen Pharmaceutica but was never marketed.

See also

• Typical antipsychotic
• Diphenylbutylpiperidine

Notes and References

1. De Cuyper HJ, Van Praag HM, Mulder WR . Therapeutical significance of clopimozide in the treatment of chronic psychotic patients . Acta Psychiatrica Scandinavica . 59 . 5 . 561–74 . May 1979 . 37697 . 10.1111/j.1600-0447.1979.tb00256.x. 30954603 .
2. Knapen J, Bollen J, Brugmanns J, Rombaut N . [Treatment of chronic psychoses with oral clopimozide] . fr . Acta Psychiatrica Belgica . 76 . 4 . 644–57 . 1976 . 798469 .
3. Janssen PA, Niemegeers CJ, Schellekens KH, Lenaerts FM, Wauquier A . Clopimozide (R 29 764), a new highly potent and orally long-acting neuroleptic of the diphenylbutylpiperidine series . Arzneimittel-Forschung . 25 . 8 . 1287–94 . August 1975 . 1242360 .
4. Floru L, Tegeler J . Clinical experiments with the new oral long-acting neuroleptic clopimozide (R 29 764) . Arzneimittel-Forschung . 28 . 2 . 341–4 . 1978 . 25071 .
5. Bobon J, Parent M, Toussaint C, Pinchard A . [Long-acting neuroleptics. IV. Preliminary study of clopimozide (R 29764)] . fr . Acta Psychiatrica Belgica . 76 . 1 . 138–43 . 1976 . 970182 .