CLDN3 explained

Claudin 3, also known as CLDN3, is a protein which in humans is encoded by the CLDN3 gene.^[1] It is a member of the claudin protein family.

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are composed of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intron-less gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares amino acid sequence similarity with a putative apoptosis-related protein found in rat.

Interactions

CLDN3 has been shown to interact with CLDN1^[2] and CLDN5.^[2]

Further reading

• Kniesel U, Wolburg H . Tight junctions of the blood-brain barrier . Cell. Mol. Neurobiol. . 20 . 1 . 57–76 . 2000 . 10690502 . 10.1023/A:1006995910836 . 26473781 .
• Heiskala M, Peterson PA, Yang Y . The roles of claudin superfamily proteins in paracellular transport . Traffic . 2 . 2 . 93–8 . 2001 . 11247307 . 10.1034/j.1600-0854.2001.020203.x . free .
• Tsukita S, Furuse M, Itoh M . Multifunctional strands in tight junctions . Nat. Rev. Mol. Cell Biol. . 2 . 4 . 285–93 . 2001 . 11283726 . 10.1038/35067088 . 36524601 .
• Tsukita S, Furuse M . Claudin-based barrier in simple and stratified cellular sheets . Curr. Opin. Cell Biol. . 14 . 5 . 531–6 . 2002 . 12231346 . 10.1016/S0955-0674(02)00362-9 .
• González-Mariscal L, Betanzos A, Nava P, Jaramillo BE . Tight junction proteins . Prog. Biophys. Mol. Biol. . 81 . 1 . 1–44 . 2003 . 12475568 . 10.1016/S0079-6107(02)00037-8 . free .
• Katahira J, Sugiyama H, Inoue N, Horiguchi Y, Matsuda M, Sugimoto N . Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo . J. Biol. Chem. . 272 . 42 . 26652–8 . 1997 . 9334247 . 10.1074/jbc.272.42.26652 . free .
• Peacock RE, Keen TJ, Inglehearn CF . Analysis of a human gene homologous to rat ventral prostate.1 protein . Genomics . 46 . 3 . 443–9 . 1997 . 9441748 . 10.1006/geno.1997.5033 .
• Morita K, Furuse M, Fujimoto K, Tsukita S . Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands . Proc. Natl. Acad. Sci. U.S.A. . 96 . 2 . 511–6 . 1999 . 9892664 . 15167 . 10.1073/pnas.96.2.511 . 1999PNAS...96..511M . free .
• Furuse M, Sasaki H, Tsukita S . Manner of interaction of heterogeneous claudin species within and between tight junction strands . J. Cell Biol. . 147 . 4 . 891–903 . 1999 . 10562289 . 2156154 . 10.1083/jcb.147.4.891 .
• Itoh M, Furuse M, Morita K, Kubota K, Saitou M, Tsukita S . Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins . J. Cell Biol. . 147 . 6 . 1351–63 . 1999 . 10601346 . 2168087 . 10.1083/jcb.147.6.1351 .
• Miyamori H, Takino T, Kobayashi Y, Tokai H, Itoh Y, Seiki M, Sato H . Claudin promotes activation of pro-matrix metalloproteinase-2 mediated by membrane-type matrix metalloproteinases . J. Biol. Chem. . 276 . 30 . 28204–11 . 2001 . 11382769 . 10.1074/jbc.M103083200 . free . 2297/15688 . free .
• Long H, Crean CD, Lee WH, Cummings OW, Gabig TG . Expression of Clostridium perfringens enterotoxin receptors claudin-3 and claudin-4 in prostate cancer epithelium . Cancer Res. . 61 . 21 . 7878–81 . 2001 . 11691807 .
• Katoh M, Katoh M . CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family . Int. J. Mol. Med. . 11 . 6 . 683–9 . 2003 . 12736707 . 10.3892/ijmm.11.6.683 .
• Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS . A systems proteomics view of the endogenous human claudin protein family . J Proteome Res . 15 . 2 . 339–359 . 2015 . 26680015 . 10.1021/acs.jproteome.5b00769 . 4777318 .

Notes and References

1. Web site: Entrez Gene: CLDN3 claudin 3.
2. Coyne CB, Gambling TM, Boucher RC, Carson JL, Johnson LG . Role of claudin interactions in airway tight junctional permeability . Am. J. Physiol. Lung Cell Mol. Physiol. . 285 . 5 . L1166-78 . Nov 2003 . 12909588 . 10.1152/ajplung.00182.2003 .