Class C GPCR explained

The class C G-protein-coupled receptors are a class of G-protein coupled receptors that include the metabotropic glutamate receptors and several additional receptors.[1]

Structurally they are composed of four elements; an N-terminal signal sequence; a large hydrophilic extracellular agonist-binding region containing several conserved cysteine residues which could be involved in disulphide bonds; a shorter region containing seven transmembrane domains; and a C-terminal cytoplasmic domain of variable length. This protein family includes metabotropic glutamate receptors, the extracellular calcium-sensing receptors, the gamma-amino-butyric acid (GABA) type B receptors, and the vomeronasal type-2 receptors.

Subfamilies

Calcium-sensing receptor-related

GABAB receptors

Metabotropic glutamate receptors

RAIG

Taste receptors

Orphan

Other

Notes and References

  1. Bräuner-Osborne H, Wellendorph P, Jensen AA . Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors . Curr Drug Targets . 8 . 1 . 169–84 . 2007 . 17266540 . 10.2174/138945007779315614 .