Cis-1,2-dihydrobenzene-1,2-diol dehydrogenase explained

cis-1,2-dihydrobenzene-1,2-diol dehydrogenase
Ec Number:	1.3.1.19
Cas Number:	51923-03-6
Go Code:	0018504

In enzymology, a cis-1,2-dihydrobenzene-1,2-diol dehydrogenase is an enzyme that catalyzes the chemical reaction

cis-1,2-dihydrobenzene-1,2-diol + NAD⁺

\rightleftharpoons catechol + NADH + H⁺

Thus, the two substrates of this enzyme are cis-1,2-dihydrobenzene-1,2-diol and NAD⁺, whereas its 3 products are catechol, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cis-1,2-dihydrobenzene-1,2-diol:NAD+ oxidoreductase. Other names in common use include cis-benzene glycol dehydrogenase, cis-1,2-dihydrocyclohexa-3,5-diene (nicotinamide adenine, and dinucleotide) oxidoreductase. This enzyme participates in 4 metabolic pathways: gamma-hexachlorocyclohexane degradation, toluene and xylene degradation, naphthalene and anthracene degradation, and styrene degradation.

References

• Axcell BC, Geary PJ . 1973 . The metabolism of benzene by bacteria. Purification and some properties of the enzyme cis-1,2-dihydroxycyclohexa-3,5-diene (nicotinamide adenine dinucleotide) oxidoreductase (cis-benzene glycol dehydrogenase) . Biochem. J. . 136 . 927 - 34 . 4362337 . 4 . 1166042 .
• Gibson DT, Koch JR, Kallio RE . 1968 . Oxidative degradation of aromatic hydrocarbons by microorganisms. I Enzymatic formation of catechol from benzene . Biochemistry . 7 . 2653 - 62 . 4298226 . 10.1021/bi00847a031 . 7 .